Intermediate Potency | Solid Dose Mfg. | Solid Dose Pkg. |  Other Mfg. and Pkg.

Our solid dose capabilities include the manufacture of tablets and capsules, as well as the production of intermediate potency drugs in our Containment Suite.

Intermediate Potency
The Containment Facility is a specialized "plant within a plant", designed to blend, tablet and coat high potency, dry blend pharmaceuticals under contained conditions. The facility's production and environmental conditions are continuously monitored to ensure optimal product quality.

The Containment Facility follows the rigorous clean design principles targeting class 100,000 air. Its structural features are easily cleaned and not conducive to retaining dust. It has its own HVAC system with a cascading air-flow, designed to keep product dust that may be released during operation in the room where it originates. In addition, HEPA filters on the supply and return air ducts further reduce the risk of contaminating other rooms.

The facility’s standard equipment is enhanced to run compounds of higher potency. All connections for the transfer of powder are via a retractable hard pipe connection called a spool piece, which is dust-tight. Most operations and cleaning systems are automated, to limit operator exposure to the compounds. The Containment Facility also has its own purified water system that meets USP codes.

Solid Dose Manufacturing
We specialize in the manufacture of tablet and capsule solid dose forms, although we also have experience and capability to handle semi-solid and liquid dosage forms. Our quality systems group issues and maintains raw material, intermediate and product specifications from customers, while the quality control laboratory handles the testing of those materials during the production process.

Blenders
Our blending capability includes jacketed Patterson-Kelley V-blenders equipped with intensifier bars to assist in material distribution or to create granulations, Bohle blenders, a tote tumble blender, and Nauta Vertical-auger mixers, designed to provide mixing where gentle handling of the materials is mandatory.

Tablets
A full complement of compression equipment enables short run and high volume tablet production. Tablet Press equipment includes: Fette 2090, Fette 2200, Mark II, Express and Hata presses.

Finishing capabilities include the application of solvent or aqueous coatings. Printing capability exists for small and large volume needs, including a rotogravure roll print and a high speed printing system that can handle 5000 tablets per minute.

Capsules
Powdered drug encapsulation capability includes dual and single plug. Equipment includes Bosch, H&K and MG-2 encapsulators.  Our Bosch is configured to fill a liquid or semi-solid into a hard gel capsule.  It can also fill tablets, beads, or powders.

Granulation

 We offer fluid bed processing / drying capabilities in our Aeromatic MP-5 system.  Our Vector GMX 600 High Shear Mixer is also available for granulation / mixing.  Both are located in an Intermediate Potency capable suite.

Solid Dose Packaging
Our solid dose packaging capabilities include blister packaging and bottling. We exercise the same care with packaging that we do with every other aspect of production. Our Quality Assurance Group inspects all incoming packaging components and issues and maintains all packaging orders, directions and component specifications.

Blister Packaging
Equipment includes a Klockner Blister line capable of thermoforming cards with a wide range of sizes based on your requirements.  We also have the capability to do carding.

Bottling
Multiple packaging lines are available to provide our customers with bottle packaging. Our highest-speed and most automated line has segregated rooms for each stage of packaging - bottle orientation & cleaning, filling & capping, and labeling & final box packaging.  We have both slat and slatless fillers for solid dose.

Compliance-designed bottling equipment with rapid changeover capability provides a wide range of counts and sizes to meet most any customer need. Multiple bottle fill lines enable both short run and high volume capability. Integrated vision systems automatically ensure proper fill counts and labeling; multiple labels and formats can be applied. An automated case packer and palletizer ensure cost effective and efficient operations.

Ointment/Liquid
Our Ointment and Liquid Manufacturing capabilities include two 1000 and one 2000 gallon Cherry Burrell jacketed mixing tanks. We also have a variety of Cherry Burrell and Groen jacketed mixing vessels ranging from 200-300 gallons. To compliment the larger tanks, we have several 200 and 172-gallon "Day" holding tanks, including several with Lightnin' mixers and heating capabilities.

Liquids Packing
We have a wide range of proven bottle filling capability, ranging from 1 oz to 500 ml bottles across various viscosities. Our bottle handling equipment can work with glass or plastic bottles.

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